Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging
Författare
Summary, in English
The bacterium Helicobacter pylori is the causative agent for peptic ulcer disease. Bacterial adherence to the human gastric epithelial lining is mediated by the fucosylated Lewis b (Leb) histo-blood group antigen. The Leb-binding adhesin, BabA, was purified by receptor activity-directed affinity tagging. The bacterial Leb-binding phenotype was associated with the presence of the cag pathogenicity island among clinical isolates of H. pylori. A vaccine strategy based on the BabA adhesin might serve as a means to target the virulent type I strains of H. pylori.
Avdelning/ar
Publiceringsår
1998
Språk
Engelska
Sidor
373-377
Publikation/Tidskrift/Serie
Science
Volym
279
Issue
5349
Dokumenttyp
Artikel i tidskrift
Förlag
American Association for the Advancement of Science (AAAS)
Ämne
- Infectious Medicine
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1095-9203