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Plasma-derived proteins in airway defence, disease and repair of epithelial injury

In English

Författare

Summary, in English

One significant characteristic of the airway mucosa in vivo, that cannot easily be mimicked in vitro, is its microcirculation, which generates a highly dynamic, biologically active milieu of plasma-derived molecules that may pass to the airway lumen in vivo. New data on the mechanisms of airway mucosal exudation indicate that the protein systems of circulating plasma may contribute significantly to the biology and immunology of the lamina propria, its surface epithelium and the luminal surface, not only in injured airways, but also in airways that are activated but display no sign of oedema, epithelial disruption, or increased absorption capacity. We suggest that present knowledge of the mechanisms of plasma exudation, together with rapidly emerging information (not detailed herein) on receptors, target cells and cellular responses to the plasma-derived molecules, must be considered in any realistic model that investigates "immuno-inflammatory" mechanisms of the airway mucosa.

Publiceringsår

1998

Språk

Engelska

Sidor

958-970

Publikation/Tidskrift/Serie

European Respiratory Journal

Volym

11

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

European Respiratory Society

Ämne

  • Respiratory Medicine and Allergy

Nyckelord

  • plasma proteins
  • Mucosal biology in vivo
  • plasma exudation

Status

Published

Forskningsgrupp

  • Airway Inflammation and Immunology

ISBN/ISSN/Övrigt

  • ISSN: 1399-3003