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Long-term effects of diltiazem and atenolol on blood glucose, serum lipids, and serum urate in hypertensive patients. Swedish-Finnish Study Group

In English

Författare

Summary, in English

The purpose of this long-term treatment study was to evaluate health-related quality of life by comparing the effects of diltiazem and atenolol on some important metabolic parameters. SUBJECTS, MATERIAL AND METHODS: In a Swedish-Finnish long-term multicenter study 256 patients with mild to moderate hypertension were randomized to treatment with diltiazem retard (D) (n = 127) or atenolol (A) (n = 129). Doses could be increased and additional captopril medication be given to achieve adequate blood pressure (BP) reduction. The treatment in group D lasted for two years while group A was treated for 1 year and then was given D for another 2 years. RESULTS: After 1 year BP was significantly reduced in both groups and to a similar degree. The BP reduction was maintained during the rest of the study. After 1 and 2 years, HDL had increased significantly (p < 0.001) in group D. There was a corresponding significant reduction of the LDL/HDL ratio. In group A there were no changes after 1 year regarding lipoprotein levels. After the switch to D, group A showed similar improvements regarding HDL and the LDL/HDL ratio as the original D group. CONCLUSION: It is concluded that D and A are equally effective in lowering BP. However, long-term treatment with D, but not with A, has a favorable effect on HDL concentrations and the LDL/HDL ratio. According to these findings D affects the risk factor profile in hypertension.

Publiceringsår

1999

Språk

Engelska

Sidor

28-33

Publikation/Tidskrift/Serie

International Journal of Clinical Pharmacology and Therapeutics

Volym

37

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Dustri-Verlag

Ämne

  • Pharmacology and Toxicology

Nyckelord

  • Diltiazem
  • Coronary vasodilator agent
  • Antiarrhythmic agent
  • Atenolol
  • Calcium antagonist
  • Antianginal agent
  • Biological activity
  • Cardioprotective agent
  • Hypertension
  • Metabolism
  • Glucose
  • Lipids
  • Uric acid
  • Human
  • Long term
  • Quality of life
  • Multicenter study
  • Randomization
  • Comparative study
  • Lipoprotein LDL
  • Lipoprotein HDL
  • Benzothiazepine derivatives
  • Risk factor
  • Cardiovascular disease

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0946-1965