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Structural studies of cysteine proteases and their inhibitors

In English

Författare

  • Zbigniew Grzonka
  • Elzbieta Jankowska
  • Franciszek Kasprzykowski
  • Regina Kasprzykowska
  • Leszek Lankiewicz
  • Wieslaw Wiczk
  • Ewa Wieczerzak
  • Jerzy Ciarkowski
  • Piotr Drabik
  • Robert Janowski
  • Maciej Kozak
  • Mariusz Jaskolski
  • Anders Grubb
Visa allt

Summary, in English

Cysteine proteases (CPs) are responsible for many biochemical processes occurring in living organisms and they have been implicated in the development and progression of several diseases that involve abnormal protein turnover. The activity of CPs is regulated among others by their specific inhibitors: cystatins. The main aim of this review is to discuss the structure-activity relationships of cysteine proteases and cystatins, as well as of some synthetic inhibitors of cysteine proteases structurally based on the binding fragments of cystatins.

Publiceringsår

2001

Språk

Engelska

Sidor

1-20

Publikation/Tidskrift/Serie

Acta Biochimica Polonica

Volym

48

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Panstwowe Wydawnictwo Naukowe

Ämne

  • Medicinal Chemistry
  • Pharmacology and Toxicology

Nyckelord

  • structure-activity relationship
  • synthetic inhibitors
  • cystatins
  • cysteine proteases

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0001-527X