Javascript is not activated in your browser. This website needs javascript activated to work properly.
Du är här

Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect

  • Karin Aase
  • Gabriel von Euler
  • Xuri Li
  • Annica Pontén
  • Peter Thoren
  • Renhai Cao
  • Yihai Cao
  • Birgitta Olofsson
  • Samuel Gebre-Medhin
  • Milos Pekny
  • Kari Alitalo
  • Christer Betsholtz
  • Ulf Eriksson
Publiceringsår: 2001
Språk: Engelska
Publikation/Tidskrift/Serie: Circulation
Volym: 104
Nummer: 3
Dokumenttyp: Artikel
Förlag: American Heart Association, Inc.


BACKGROUND: Vascular endothelial growth factors (VEGFs) and their receptors are essential regulators of vasculogenesis and angiogenesis in both embryos and adults. One of the factors with a still unknown physiological function is VEGF-B, which is expressed in many tissues, including the heart. METHODS AND RESULTS: Mice carrying a targeted deletion in the VEGF-B gene were developed. In VEGF-B(-/-) animals, no gross abnormalities were observed in organs that normally show high expression of VEGF-B, such as the heart, muscle, and kidney. Analysis of heart function by ECG showed that adult VEGF-B(-/-) mice have an atrial conduction abnormality characterized by a prolonged PQ interval. VEGF- or basic fibroblast growth factor-induced corneal angiogenesis was similar in normal and VEGF-B(-/-) mice. CONCLUSIONS: VEGF-B seems to be required for normal heart function in adult animals but is not required for proper development of the cardiovascular system either during development or for angiogenesis in adults.



  • Medicine and Health Sciences
  • electrocardiography
  • growth substances
  • angiogenesis
  • atrium
  • conduction


  • ISSN: 1524-4539

Box 117, 221 00 LUND
Telefon 046-222 00 00 (växel)
Telefax 046-222 47 20
lu [at] lu [dot] se

Fakturaadress: Box 188, 221 00 LUND
Organisationsnummer: 202100-3211
Om webbplatsen