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Experimental nerve compression and upregulation of CPON in DRG

Författare:
Publiceringsår: 2001
Språk: Engelska
Sidor: 3783-3786
Publikation/Tidskrift/Serie: NeuroReport
Volym: 12
Nummer: 17
Dokumenttyp: Artikel
Förlag: Lippincott Williams & Wilkins

Sammanfattning

Expression of C-terminal flanking peptide of neuropeptide Y (CPON) in DRG and cell proliferation (incorporation of BrdU) in sciatic nerve of rats following chronic nerve compression (silicone tubes with different internal diameters) was studied by immunocytochemistry. An increased number of CPON-positive neurons and cells incorporating BrdU was induced on the compressed side, most pronounced when a tight tube was used, while no cells expressed CPON or BrdU in intact nerves. The increase was transient and declined with time. Nerve compression induces transient cell proliferation in the nerve and expression of CPON in nerve cell bodies, but this is of a lesser magnitude than those following nerve transection.

Disputation

Nyckelord

  • Medicine and Health Sciences

Övriga

Published
Yes
  • ISSN: 0959-4965

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