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Different molecular mechanisms underlie placental overgrowth phenotypes caused by interspecies hybridization, cloning, and Esx1 mutation

  • Umashankar Singh
  • Laurel E Fohn
  • Teruhiko Wakayama
  • Jun Ohgane
  • Christine Steinhoff
  • Bettina Lipkowitz
  • Ralph Schulz
  • Annie Orth
  • H Hilger Ropers
  • Richard R Behringer
  • Satoshi Tanaka
  • Kunio Shiota
  • Ryuzo Yanagimachi
  • Ulrike Nuber
Publiceringsår: 2004
Språk: Engelska
Sidor: 149-164
Publikation/Tidskrift/Serie: Developmental dynamics : an official publication of the American Association of Anatomists
Volym: 230
Nummer: 1
Dokumenttyp: Artikel
Förlag: Wiley


To obtain a deeper insight into the genes and gene networks involved in the development of placentopathies, we have assessed global gene expression in three different models of placental hyperplasia caused by interspecies hybridization (IHPD), cloning by nuclear transfer, and mutation of the Esx1 gene, respectively. Comparison of gene expression profiles of approximately 13,000 expressed sequence tags (ESTs) identified specific subsets of genes with changed expression levels in IHPD, cloned, and Esx1 mutant placentas. Of interest, only one gene of known function and one EST of unknown function were found common to all three placentopathies; however, a significant number of ESTs were common to IHPD and cloned placentas. In contrast, only one gene was shared between IHPD and Esx1 mutant, and cloned and Esx1 mutant placentas, respectively. These genes common to different abnormal placental growth genotypes are likely to be important in the occurrence of placentopathy.



  • Medicine and Health Sciences


  • ISSN: 1058-8388

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