The environmental determinants of diabetes in the young (TEDDY) study: Study design

Summary, in English

The primary objective of this multicenter, multinational, epidemiological study is the identification of infectious agents, dietary factors, or other environmental exposures that are associated with increased risk of autoimmunity and type 1 diabetes mellitus (T1DM). Factors affecting specific phenotypic manifestations such as early age of onset or rate of progression or with protection from the development of T1DM will also be identified. The Environmental Determinants of Diabetes in the Young (TEDDY) is an observational cohort study in which newborns who are younger than 4 months and have high-risk human leukocyte antigen alleles in the general population or are first-degree relatives (FDRs) of patients affected with T1DM will be enrolled. Six clinical centers in the USA and Europe will screen 361 588 newborns, of which it is anticipated that 17 804 will be eligible for enrollment with just over 7800 followed. Recruitment will occur over 5 yr, with children being followed to the age of 15 yr. Identification of such factors will lead to a better understanding of disease pathogenesis and result in new strategies to prevent, delay, or reverse T1DM.

• Författare: The TEDDY study group; Åke Lernmark; Peter Almgren; Carin Andrén Aronsson; Eva Andersson; Sylvia Bianconi Svensson; Ulla-Marie Carlsson; Corrado Cilio; Joanna Gerardsson; Barbro Gustavsson; Anna Hansson; Gertie Hansson; Ida Jönsson; Sten Ivarsson; Helena Larsson; Elli Karlsson; Anastasia Papadopoulou; Barbro Lernmark; Theodosia Massadakis; Anita Ramelius; Monica Sedig-Järvirova; Birgitta Sjöberg; Anne Wallin; Åsa Wimar
• Avdelning/ar: Celiaki och diabetes; Institutionen för kliniska vetenskaper, Malmö; Pediatrisk endokrinologi
• Publiceringsår: 2007
• Språk: Engelska
• Sidor: 286-298
• Publikation/Tidskrift/Serie: Pediatric Diabetes
• Volym: 8
• Issue: 5
• Länkar: http://dx.doi.org/10.1111/j.1399-5448.2007.00269.x
• Dokumenttyp: Artikel i tidskrift
• Förlag: Wiley-Blackwell
• Ämne: Endocrinology and Diabetes; Pediatrics
• Nyckelord: psychosocial factors; infectious agents factors; islet autoimmunity; HLA; epidemiological study; environmental triggers; dietary factors; T1DM
• Status: Published
• Forskningsgrupp: Celiac Disease and Diabetes Unit; Paediatric Endocrinology
• ISBN/ISSN/Övrigt: ISSN: 1399-543X