Pericytes: gatekeepers in tumour cell metastasis?
Författare
Summary, in English
Tumour cells use two major routes to spread during metastasis, e.g. lymph vessels and blood vessels within or surrounding the primary tumour. The growth rate of the primary tumour often correlates with the quantity of new blood vessels that form within the tumour. However, qualitative abnormalities of the tumour vasculature profoundly affect the perfusion of the primary tumour and the escape of tumour cells into the circulation. In this paper, we review recent evidence for a novel role of the supporting mural cells in limiting blood-borne metastasis.
Avdelning/ar
Publiceringsår
2008
Språk
Engelska
Sidor
135-144
Publikation/Tidskrift/Serie
Journal of Molecular Medicine
Volym
86
Issue
2
Dokumenttyp
Artikel i tidskrift
Förlag
Springer
Ämne
- Cell and Molecular Biology
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1432-1440