An improved method for detecting and delineating genomic regions with altered gene expression in cancer

Summary, in English

ABSTRACT: Genomic regions with altered gene expression are a characteristic feature of cancer cells. We present a novel method for identifying such regions in gene expression maps. This method is based on total variation (TV) minimization, a classical signal restoration technique. In systematic evaluations, we show that our method combines top-notch detection performance with an ability to delineate relevant regions without excessive over-segmentation, making it a significant advance over existing methods. Software (Rendersome) is provided.

• Författare: Björn Nilsson; Mikael Johansson; Anders Heyden; Sven Nelander; Thoas Fioretos
• Avdelning/ar: Avdelningen för hematologi och transfusionsmedicin; Hematogenomics; Avdelningen för klinisk genetik
• Publiceringsår: 2008
• Språk: Engelska
• Publikation/Tidskrift/Serie: Genome Biology
• Volym: 9
• Issue: 1
• Länkar: http://dx.doi.org/10.1186/gb-2008-9-1-r13
• Dokumenttyp: Artikel i tidskrift
• Förlag: BioMed Central (BMC)
• Ämne: Medical Genetics
• Status: Published
• Forskningsgrupp: Hematogenomics
• ISBN/ISSN/Övrigt: ISSN: 1474-7596