Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.
Författare
Summary, in English
Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein-positive Lewy bodies in grafted neurons. Our observation has key implications for understanding Parkinson's pathogenesis by providing the first evidence, to our knowledge, that the disease can propagate from host to graft cells. However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief.
Avdelning/ar
Publiceringsår
2008
Språk
Engelska
Sidor
501-503
Publikation/Tidskrift/Serie
Nature Medicine
Volym
14
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Nature Publishing Group
Ämne
- Neurosciences
- Neurology
Status
Published
Forskningsgrupp
- Neural Plasticity and Repair
- Neurobiology
ISBN/ISSN/Övrigt
- ISSN: 1546-170X