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Tissue reactions evoked by porous and plane surfaces made out of silicon and titanium.

Författare

Summary, in English

Square-shaped silicon or titanium implants with plane or porous surfaces surrounded by a rim of silicone were implanted in the rat abdominal wall for evaluation of the tissue response after one, six, or 12 weeks. Cell damage was identified as increased membrane permeability using fluorescence microscopy by injection of propidium iodide prior to the killing of the rats. Capsule thickness and immunohistochemical quantification of macrophages were used as a further measure of the foreign-body reaction. There were no significant differences in capsular cell densities for macrophages, total cells (macrophages, fibroblasts, and other cells), or necrotic cells at the different time points for the four surfaces studied. However, significant differences in the kinetics of the response were found between plane surfaces compared with porous ones. Both types of plane surfaces developed a significant increase in capsule thickness over time in contrast to the porous implants. Porous silicon displayed a significant decrease in total cells in the reactive capsule over time. Furthermore, porous silicon and titanium surfaces displayed a significant decrease in total cell numbers at the implant interface between six and 12 weeks. The present study demonstrated that implanted silicon elicited soft-tissue reactions comparable to that of titanium

Publiceringsår

2002

Språk

Engelska

Sidor

392-399

Publikation/Tidskrift/Serie

IEEE Transactions on Biomedical Engineering

Volym

49

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

IEEE - Institute of Electrical and Electronics Engineers Inc.

Ämne

  • Medical Engineering

Nyckelord

  • Rats
  • Prosthesis Design
  • Titanium
  • Support
  • Non-U.S. Gov't
  • Nonparametric
  • Statistics
  • Sprague-Dawley
  • Silicon
  • Foreign-Body Reaction: pathology
  • Cell Membrane Permeability
  • Image Processing
  • Animal
  • Biocompatible Materials
  • Microscopy
  • Abdominal Muscles
  • Male
  • Immunoenzyme Techniques
  • Computer-Assisted
  • Prostheses and Implants: adverse effects
  • Fluorescence

Status

Published

Forskningsgrupp

  • Neural Interfaces

ISBN/ISSN/Övrigt

  • ISSN: 1558-2531