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Chaperones and folding of MHC class I molecules in the endoplasmic reticulum.

In English

Författare

Summary, in English

In this review we discuss the influence of chaperones on the general phenomena of folding as well as on the specific folding of an individual protein, MHC class I. MHC class I maturation is a highly sophisticated process in which the folding machinery of the endoplasmic reticulum (ER) is heavily involved. Understanding the MHC class I maturation per se is important since peptides loaded onto MHC class I molecules are the base for antigen presentation generating immune responses against virus, intracellular bacteria as well as tumours. This review discusses the early stages of MHC class I maturation regarding BiP and calnexin association, and differences in MHC class I heavy chain (HC) interaction with calnexin and calreticulin are highlighted. Late stage MHC class I maturation with focus on the dedicated chaperone tapasin is also discussed. (C) 2003 Elsevier Science B.V. All rights reserved.

Publiceringsår

2003

Språk

Engelska

Sidor

1-12

Publikation/Tidskrift/Serie

Biochimica et Biophysica Acta

Volym

1641

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Cell and Molecular Biology

Nyckelord

  • chaperone
  • tapasin
  • endoplasmic reticulum (ER)
  • MEC class I
  • folding

Status

Published

Forskningsgrupp

  • Antigen Presentation

ISBN/ISSN/Övrigt

  • ISSN: 0006-3002