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An extract of Uncaria tomentosa inhibiting cell division and NF-kappaB activity without inducing cell death.

Författare

  • Christina Silver
  • Hanna Lindgren
  • Ronald Pero
  • Tomas Leanderson
  • Fredrik Ivars

Summary, in English

Previous reports have demonstrated that extracts of the plant Uncaria tomentosa inhibit tumor cell proliferation and inflammatory responses. We have confirmed that C-Med 100®, a hot water extract of this plant, inhibits tumor cell proliferation albeit with variable efficiency. We extend these findings by showing that this extract also inhibits proliferation of normal mouse T and B lymphocytes and that the inhibition is not caused by toxicity or by induction of apoptosis. Further, the extract did not interfere with IL-2 production nor IL-2 receptor signaling. Since there was no discrete cell cycle block in C-Med 100®-treated cells, we propose that retarded cell cycle progression caused the inhibition of proliferation. Collectively, these data suggested interference with a common pathway controlling cell growth and cell cycle progression. Indeed, we provide direct evidence that C-Med 100® inhibits nuclear factor κB (NF-κB) activity and propose that this at least partially causes the inhibition of proliferation.

Avdelning/ar

Publiceringsår

2003

Språk

Engelska

Sidor

1889-1900

Publikation/Tidskrift/Serie

International Immunopharmacology

Volym

3

Issue

13-14

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Pharmacology and Toxicology

Nyckelord

  • Inhibition
  • NF-κB
  • Uncaria tomentosa
  • Proliferation
  • Apoptosis

Status

Published

Forskningsgrupp

  • Diabetes - Immunovirology
  • Immunology

ISBN/ISSN/Övrigt

  • ISSN: 1878-1705