Common sequence variants on 20q11.22 confer melanoma susceptibility

Summary, in English

We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.

• Författare: Kevin M. Brown; Stuart MacGregor; Grant W. Montgomery; David W. Craig; Zhen Zhen Zhao; Kelly Iyadurai; Anjali K. Henders; Nils Homer; Megan J. Campbell; Mitchell Stark; Shane Thomas; Helen Schmid; Elizabeth A. Holland; Elizabeth M. Gillanders; David L. Duffy; Judith A. Maskiell; Jodie Jetann; Megan Ferguson; Dietrich A. Stephan; Anne E. Cust; David Whiteman; Adele Green; Håkan Olsson; Susana Puig; Paola Ghiorzo; Johan Hansson; Florence Demenais; Alisa M. Goldstein; Nelleke A. Gruis; David E. Elder; Julia Newton Bishop; Richard F. Kefford; Graham G. Giles; Bruce K. Armstrong; Joanne F. Aitken; John L. Hopper; Nicholas G. Martin; Jeffrey M. Trent; Graham J. Mann; Nicholas K. Hayward
• Avdelning/ar: Bröstcancer-genetik
• Publiceringsår: 2008
• Språk: Engelska
• Sidor: 838-840
• Publikation/Tidskrift/Serie: Nature Genetics
• Volym: 40
• Issue: 7
• Länkar: http://dx.doi.org/10.1038/ng.163
• Dokumenttyp: Artikel i tidskrift
• Förlag: Nature Publishing Group
• Ämne: Cancer and Oncology
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1546-1718