A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population

Summary, in English

Genome-wide association scans in type 2 diabetes (T2D) have identified a risk variant, rs13266634 (Arg325Trp), in SLC30A8 on chromosome 8. SLC30A8 encodes a beta-cell specific zinc-ion transporter and rs13266634 has been shown to affect insulin secretion. Recently, autoantibodies for Slc30A8 with high predictive value were demonstrated in individuals with type 1 diabetes (T1 D), making this gene an interesting T1 D candidate gene. We genotyped rs13266634 in 3008 cases and controls and 246 families from Denmark. Association to T1 D could not be demonstrated.

• Författare: Caroline Brorsson; Regine Bergholdt; Marketa Sjögren; Stefanie Eising; Karina Meden Sorensen; David M. Hougaard; Marju Orho-Melander; Leif Groop; Flemming Pociot
• Avdelning/ar: Translationell Muskel Forskning
• Publiceringsår: 2008
• Språk: Engelska
• Sidor: 386-388
• Publikation/Tidskrift/Serie: Molecular Genetics and Metabolism
• Volym: 94
• Issue: 3
• Länkar: http://dx.doi.org/10.1016/j.ymgme.2008.02.011
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Endocrinology and Diabetes
• Nyckelord: beta-cell function; genetics; type 1 diabetes; SLC30A8; zinc transporter
• Status: Published
• Forskningsgrupp: Genomics, Diabetes and Endocrinology
• ISBN/ISSN/Övrigt: ISSN: 1096-7192