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Complementary Signaling through flt3 and Interleukin-7 Receptor {alpha} Is Indispensable for Fetal and Adult B Cell Genesis.

Författare:
Publiceringsår: 2003
Språk: Engelska
Sidor: 1495-1506
Publikation/Tidskrift/Serie: Journal of Experimental Medicine
Volym: 198
Nummer: 10
Dokumenttyp: Artikel
Förlag: Rockefeller University Press

Sammanfattning

Extensive studies of mice deficient in one or several cytokine receptors have failed to support an indispensable role of cytokines in development of multiple blood cell lineages. Whereas B1 B cells and Igs are sustained at normal levels throughout life of mice deficient in IL-7, IL-7R{alpha}, common cytokine receptor gamma chain, or flt3 ligand (FL), we report here that adult mice double deficient in IL-7R{alpha} and FL completely lack visible LNs, conventional IgM+ B cells, IgA+ plasma cells, and B1 cells, and consequently produce no Igs. All stages of committed B cell progenitors are undetectable in FL-/- x IL-7R{alpha}-/- BM that also lacks expression of the B cell commitment factor Pax5 and its direct target genes. Furthermore, in contrast to IL-7R{alpha}-/- mice, FL-/- x IL-7R{alpha}-/- mice also lack mature B cells and detectable committed B cell progenitors during fetal development. Thus, signaling through the cytokine tyrosine kinase receptor flt3 and IL-7R{alpha} are indispensable for fetal and adult B cell development.

Disputation

Nyckelord

  • Biology and Life Sciences
  • IL-7 receptor
  • Flt3 ligand
  • B1 cells
  • Pax5
  • lymphopoiesis

Övriga

Published
Yes
  • ISSN: 0022-1007

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