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Norovirus strains belonging to the GII.4 genotype dominate as a cause of nosocomial outbreaks of viral gastroenteritis in Sweden 1997-2005 - Arrival of new variants is associated with large nation-wide epidemics

In English

Författare

  • Kari Johansen
  • Kerstin Mannerqvist
  • Annika Allard
  • Yvonne Andersson
  • Lars G. Burman
  • Lena Dillner
  • Kjell-Olof Hedlund
  • Klas Jonsson
  • Urban Kumlin
  • Thomas Leitner
  • Maria Lysen
  • Margareta Thorhagen
  • Annika Tiveljung-Lindell
  • Cecilia Wahlström
  • Benita Zweygberg-Wirgart
  • Anders Widell
Visa allt

Summary, in English

Background: In recent years an increase of the incidence of nosocomial outbreaks caused by noroviruses has been observed throughout Sweden, with high peaks noted in the winter seasons 2002/2003 and 2004/2005, respectively. Objectives: To phylogenetically characterize norovirus strains causing nosocomial outbreaks from 1997 to 2005 and estimate the impact of norovirus-like disease on the Swedish health care system during the peak season 2002/2003 when a new variant of norovirus occurred. Study design: Stool samples from 115 randomly selected nosocomial outbreaks occurring during 1997-2005 throughout Sweden were studied by RT-PCR and sequencing. In addition, to investigate the impact on the health-care system, a questionnaire was distributed to infection control units (n = 90) serving all Swedish hospitals, nursing homes and other health-care institutions during the largest epidemic of nosocomial outbreaks. Results: Sequencing of 279 nucleotides of the norovirus RNA polymerase gene in stools containing norovirus RNA showed that strains belonging to the GII.4 genotype dominated. Each of the two large epidemics was due to a new variant within this cluster. The questionnaire revealed that 30,000-35,000 episodes of nosocomial norovirus-like infections occurred in 80 of 82 major Swedish hospitals affected in 2002/2003. Conclusion: New norovirus variants within the cluster GGII.4 may have a major impact on the health-care system. (c) 2008 Elsevier B.V. All rights reserved.

Publiceringsår

2008

Språk

Engelska

Sidor

129-134

Publikation/Tidskrift/Serie

Journal of Clinical Virology

Volym

42

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Infectious Medicine

Nyckelord

  • health-care associated infections
  • norovirus
  • molecular epidemiology

Status

Published

Forskningsgrupp

  • Clinical Microbiology, Malmö

ISBN/ISSN/Övrigt

  • ISSN: 1386-6532