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Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory

Författare

  • Cord Brakebusch
  • Constanze I. Seidenbecher
  • Fredrik Asztély
  • Uwe Rauch
  • Henry Matthies
  • Hannelore Meyer
  • Manfred Krug
  • Tobias M. Böckers
  • Xiaohong Zhou
  • Michael R. Kreutz
  • Dirk Montag
  • Eckart D. Gundelfinger
  • Reinhard Fässler

Summary, in English

Brevican is a brain-specific proteoglycan which is found in specialized extracellular matrix structures called perineuronal nets. Brevican increases the invasiveness of glioma cells in vivo and has been suggested to play a role in central nervous system fiber tract development. To study the role of brevican in the development and function of the brain, we generated mice lacking a functional brevican gene. These mice are viable and fertile and have a normal life span. Brain anatomy was normal, although alterations in the expression of neurocan were detected. Perineuronal nets formed but appeared to be less prominent in mutant than in wild-type mice. Brevican-deficient mice showed significant deficits in the maintenance of hippocampal long-term potentiation (LTP). However, no obvious impairment of excitatory and inhibitory synaptic transmission was found, suggesting a complex cause for the LTP defect. Detailed behavioral analysis revealed no statistically significant deficits in learning and memory. These data indicate that brevican is not crucial for brain development but has restricted structural and functional roles.

Publiceringsår

2002

Språk

Engelska

Sidor

7417-7427

Publikation/Tidskrift/Serie

Molecular and Cellular Biology

Volym

22

Issue

21

Dokumenttyp

Artikel i tidskrift

Förlag

American Society for Microbiology

Ämne

  • Cancer and Oncology
  • Neurology

Status

Published

Forskningsgrupp

  • Vessel Wall Biology

ISBN/ISSN/Övrigt

  • ISSN: 0270-7306