The role of SPINK1 in ETS rearrangement-negative prostate cancers
Författare
Summary, in English
ETS gene fusions have been characterized in a majority of prostate cancers; however, the key molecular alterations in ETS-negative cancers are unclear. Here we used an outlier meta-analysis (meta-COPA) to identify SPINK1 outlier expression exclusively in a subset of ETS rearrangement-negative cancers (similar to 10% of total cases). We validated the mutual exclusivity of SPINK1 expression and ETS fusion status, demonstrated that SPINK1 outlier expression can be detected noninvasively in urine, and observed that SPINK1 outlier expression is an independent predictor of biochemical recurrence after resection. We identified the aggressive 22RV1 cell line as a SPINK1 outlier expression model and demonstrate that SPINK1 knockdown in 22RV1 attenuates invasion, suggesting a functional role in ETS rearrangement-negative prostate cancers.
Publiceringsår
2008
Språk
Engelska
Sidor
519-528
Publikation/Tidskrift/Serie
Cancer Cell
Volym
13
Issue
6
Dokumenttyp
Artikel i tidskrift
Förlag
Cell Press
Ämne
- Cancer and Oncology
Nyckelord
- CELLBIO
- HUMDISEASE
Status
Published
Forskningsgrupp
- Clinical Chemistry, Malmö
- Urological cancer, Malmö
ISBN/ISSN/Övrigt
- ISSN: 1878-3686