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Lung function in relation to 2-thiothiazolidine-4-carboxylic Acid and genetic effect modification among rubber workers in sweden.

Publiceringsår: 2008
Språk: Engelska
Sidor: 1006-1012
Publikation/Tidskrift/Serie: Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine
Volym: 50
Nummer: 9
Dokumenttyp: Artikel

Sammanfattning

OBJECTIVE:: What is the risk of impaired lung function in contemporary Swedish rubber workers and are there modifying effects of genetic variants? METHODS:: Included in the study were 159 rubber exposed and 118 not-rubber exposed workers. Lung function was analyzed as forced vital capacity percent of predicted and forced expiratory volume in 1 second percent of predicted. Levels of 2-thiothiazolidine-4-carboxylic acid (a marker of carbon disulfide and vulcanization fumes) was assessed with liquid chromatography tandem mass spectrometry. Polymorphisms in glutathione-related genes were analyzed by Taqman-based allelic discrimination and ordinary polymerase chain reaction. RESULTS:: There was an association between increasing levels of 2-thiothiazolidine-4-carboxylic acid and impaired lung function among exposed workers. The association was modified by glutathione S-transferase alpha 1 (GSTA1)-52 and GSTP1-114. GSTM1 had an influence on lung function among unexposed workers. CONCLUSIONS:: There may be a risk of impaired lung function in contemporary rubber workers. Gene-modifying effects may be considered in risk assessments.

Disputation

Nyckelord

  • Medicine and Health Sciences

Övrigt

Published
Yes
  • ISSN: 1076-2752

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