Stem cell therapy for Parkinson's disease: where do we stand?
Författare
Summary, in English
A major neuropathological feature of Parkinson's disease (PD) is the loss of nigrostriatal dopaminergic neuron. Patients exhibit motor symptoms, including bradykinesia, rigidity, and tremor. Neural grafting has been reported to restore striatial dopaminergic neurotransmission and induce symptomatic relief. The major limitation of cell replacement therapy for PD is the shortage of suitable donor tissue. The present review describes the possible sources of cells, including embryonic stem cells and somatic adult stem cells, both of which potentially could be used in cell therapy for PD, and discusses the advantages and disadvantages of each cell type.
Publiceringsår
2004
Språk
Engelska
Sidor
261-273
Publikation/Tidskrift/Serie
Cell and Tissue Research
Volym
318
Issue
1
Dokumenttyp
Artikel i tidskrift
Förlag
Springer
Ämne
- Cell Biology
Nyckelord
- Parkinson's disease
- Neural grafting
- Embryonic stem cells
- Somatic adult stem cells
Status
Published
Forskningsgrupp
- Neural Plasticity and Repair
ISBN/ISSN/Övrigt
- ISSN: 1432-0878