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Long-term testosterone stimulation induces hyperplasia in the guinea-pig prostate.

Publiceringsår: 2004
Språk: Engelska
Sidor: 227-231
Publikation/Tidskrift/Serie: Prostate Cancer and Prostatic Diseases
Volym: 7
Nummer: 3
Dokumenttyp: Artikel
Förlag: Nature Publishing Group


The relation between supraphysiologic circulating testosterone levels and prostatic diseases is unclear and difficult to study in men. Animal models may be advantageous. Based on a pilot study, testosterone enantate 50 mg (n=12) or 25 mg (n=12) was administered to guinea-pigs intramuscularly every 3 weeks, for either 7 or 14 months. The histopathology of the prostate was described. Epithelial hyperplasia was found in 14/21 animals receiving testosterone and in 7/12 very old animals, but no such changes were found in the sham or castrated animals. Testosterone stimulation seems to induce epithelial hyperplasia, but not cancer, in the guinea-pig prostate.



  • Medicine and Health Sciences
  • Biology and Life Sciences


  • ISSN: 1365-7852

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