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Identification of novel candidate protein biomarkers for the post-polio syndrome — Implications for diagnosis, neurodegeneration and neuroinflammation

Författare:
Publiceringsår: 2009
Språk: Engelska
Sidor: 670-681
Publikation/Tidskrift/Serie: Journal of Proteomics
Volym: 71
Nummer: 6
Dokumenttyp: Artikel
Förlag: Elsevier

Sammanfattning

Survivors of poliomyelitis often develop increased or new symptoms decades after the acute infection, a condition known as post-polio syndrome (PPS). The condition affects 20–60% of previous polio patients, making it one of the most common causes of neurological deficits worldwide. The underlying pathogenesis is not fully understood and accurate diagnosis is not feasible. Herein we investigated whether it was possible to identify proteomic profile
aberrations in the cerebrospinal fluid (CSF) of PPS patients.
CSF from 15 patients with well-defined PPS were analyzed for 1499 proteins. The results were compared to data obtained from ten healthy controls and 33 patients with other noninflammatory diseases which served as negative controls. In addition, 17 samples from persons with secondary progressive multiple sclerosis (SPMS) were added as relevant agematched references for the PPS samples.
The CSF of persons with PPS displayed a disease-specific and highly predictive (p=0.0017) differential expression of five distinct proteins: gelsolin, hemopexin, peptidylglycine alpha-amidating monooxygenase, glutathione synthetase and kallikrein 6, respectively, in comparison with the control groups. An independent ELISA confirmed the increase of kallikrein 6.

Disputation

Nyckelord

  • Biology and Life Sciences
  • post-polio syndrome
  • CSF
  • proteomics
  • diagnosis
  • biomarkers
  • pathophysiology

Övrigt

Published
Yes
  • ISSN: 1874-3919

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