The reductive fragmentation of 7-hydroxy-9,10-dioxotaxoids.

Summary, in English

The retro-aldol reductive fragmentation of different structural types of 7-hydroxy-9,10-dioxotaxoids was investigated, showing that the reaction is typical of taxanes and requires cerium(III) promotion with NaBH4 in protic medium and alkylboron (aluminium) hydrides in aprotic solvents. The resulting 7,8-seco-taxanes are key intermediates for the synthesis of a novel class of anticancer taxanes endowed with a unique pattern of in vivo biological activity. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)

• Författare: G Appendino; A Noncovich; P Bettoni; P Dambruoso; Olov Sterner; G Fontana; E Bombardelli
• Avdelning/ar: Centrum för analys och syntes
• Publiceringsår: 2003
• Språk: Engelska
• Sidor: 4422-4431
• Publikation/Tidskrift/Serie: European Journal of Organic Chemistry
• Volym: 2003
• Issue: 22
• Länkar: http://dx.doi.org/10.1002/ejoc.200300376
• Dokumenttyp: Artikel i tidskrift
• Förlag: John Wiley & Sons Inc.
• Ämne: Organic Chemistry
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1434-193X