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Autofluorescence insensitive imaging using upconverting nanocrystals in scattering media

Författare:
Publiceringsår: 2008
Språk: Engelska
Publikation/Tidskrift/Serie: APPLIED PHYSICS LETTERS
Volym: 93
Nummer: 17
Dokumenttyp: Artikel
Förlag: AMER INST PHYSICS

Sammanfattning

Autofluorescence is a nuisance in the field of fluorescence imaging and tomography of exogenous molecular markers in tissue, degrading the quality of the collected data. In this letter, we report autofluorescence insensitive imaging using highly efficient upconverting nanocrystals (NaYF4: Yb3+ /Tm3+) in a tissue phantom illuminated with near- infrared radiation of 85 mW/cm(2). It was found that imaging with such nanocrystals leads to an exceptionally high contrast compared to traditional downconverting fluorophores due to the absence of autofluorescence. Upconverting nanocrystals may be envisaged as important biological markers for tissue imaging purposes. c 2008 American Institute of Physics. [DOI: 10.1063/1.3005588]

Disputation

Nyckelord

  • Physics and Astronomy

Övriga

Published
Yes
  • Biophotonics
Copyright (2008) American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in (C. Xu et al., Appl. Phys. Lett. 93, 171103 (2008)) and may be found at (http://link.aip.org/link/?apl/93/171103)
  • ISSN: 0003-6951

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