Apolipoprotein M affecting lipid metabolism or just catching a ride with lipoproteins in the circulation?
Författare
Summary, in English
Apolipoprotein M (apoM) is a novel apolipoprotein found mainly in high-density lipoproteins (HDL). Its function is yet to be defined. ApoM (25 kDa) has a typical lipocalin beta-barrel fold and a hydrophobic pocket. Retinoids bind apoM but with low affinity and may not be the natural ligands. ApoM retains its signal peptide, which serves as a hydrophobic anchor to the lipoproteins. This prevents apoM from being lost in the urine. Approximately 5% of HDL carries an apoM molecule. ApoM in plasma (1 muM) correlates strongly with both low-density lipoprotein (LDL) and HDL cholesterol, suggesting a link to cholesterol metabolism. However, in casecontrol studies, apoM levels in patients with coronary heart disease (CHD) and controls were similar, suggesting apoM levels not to affect the risk for CHD in humans. Experiments in transgenic mice suggested apoM to have antiatherogenic properties; possible mechanisms include increased formation of pre-beta HDL, enhanced cholesterol mobilization from foam cells, and increased antioxidant properties.
Avdelning/ar
Publiceringsår
2009
Språk
Engelska
Sidor
559-564
Publikation/Tidskrift/Serie
Cellular and Molecular Life Sciences
Volym
66
Fulltext
- Available as PDF - 274 kB
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Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Birkhäuser Verlag
Ämne
- Cell Biology
Status
Published
Forskningsgrupp
- Clinical Chemistry, Malmö
ISBN/ISSN/Övrigt
- ISSN: 1420-9071