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The cytotoxic eosinophil cationic protein (ECP) has ribonuclease activity

Författare

Summary, in English

The eosinophil cationic protein (ECP) is a specific cytotoxic constituent of granules. In this work we demonstrated that ECP has a ribonuclease activity. Purified ECP was resolved by ion exchange chromatography into subfractions, which all showed ribonuclease activity. Another eosinophil granule protein, EPX, identical with eosinophil-derived neurotoxin (EDN) had a 125-fold higher RNase activity than ECP. ECP may exert its cytotoxic effects on parasites and cells because of its extreme basicity alone or it may be internalized and act by degrading mRNA.

Publiceringsår

1986

Språk

Engelska

Sidor

1239-1242

Publikation/Tidskrift/Serie

Biochemical and Biophysical Research Communications

Volym

139

Issue

3

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Medical and Health Sciences

Status

Published