Du är här

Formation of new chromosomes as a virulence mechanism in yeast Candida glabrata.

Författare:
  • Silvia Poláková
  • Christian Blume
  • Julián Alvarez Zárate
  • Marek Mentel
  • Dorte Jørck-Ramberg
  • Jørgen Stenderup
  • Jure Piskur (Professor)
Publiceringsår: 2009
Språk: Engelska
Sidor: 2688-2693
Publikation/Tidskrift/Serie: Proceedings of the National Academy of Sciences of the United States of America
Volym: 106
Nummer: 8
Dokumenttyp: Artikel
Förlag: National Academy of Sciences of the United States of America

Sammanfattning

In eukaryotes, the number and rough organization of chromosomes is well preserved within isolates of the same species. Novel chromosomes and loss of chromosomes are infrequent and usually associated with pathological events. Here, we analyzed 40 pathogenic isolates of a haploid and asexual yeast, Candida glabrata, for their genome structure and stability. This organism has recently become the second most prevalent yeast pathogen in humans. Although the gene sequences were well conserved among different strains, their chromosome structures differed drastically. The most frequent events reshaping chromosomes were translocations of chromosomal arms. However, also larger segmental duplications were frequent and occasionally we observed novel chromosomes. Apparently, this yeast can generate a new chromosome by duplication of chromosome segments carrying a centromere and subsequently adding novel telomeric ends. We show that the observed genome plasticity is connected with antifungal drug resistance and it is likely an advantage in the human body, where environmental conditions fluctuate a lot.

Disputation

Nyckelord

  • Biology and Life Sciences

Övrigt

Published
Yes
  • ISSN: 1091-6490

Box 117, 221 00 LUND
Telefon 046-222 00 00 (växel)
Telefax 046-222 47 20
lu [at] lu [dot] se

Fakturaadress: Box 188, 221 00 LUND
Organisationsnummer: 202100-3211
Om webbplatsen

LERU logo U21 logo