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A pooled analysis of Melanocytic nevus phenotype and the risk of cutaneous melanoma at different latitudes

In English

Författare

  • Yu-mei Chang
  • Julia A. Newton-Bishop
  • D. Timothy Bishop
  • Bruce K. Armstrong
  • Veronique Bataille
  • Wilma Bergman
  • Marianne Berwick
  • Paige M. Bracci
  • J. Mark Elwood
  • Marc S. Ernstoff
  • Adele C. Green
  • Nelleke A. Gruis
  • Elizabeth A. Holly
  • Christian Ingvar
  • Peter A. Kanetsky
  • Margaret R. Karagas
  • Loic Le Marchand
  • Rona M. Mackie
  • Håkan Olsson
  • Anne Osterlind
  • Timothy R. Rebbeck
  • Kristian Reich
  • Peter Sasieni
  • Victor Siskind
  • Anthony I. Swerdlow
  • Linda Titus-Ernstoff
  • Michael S. Zens
  • Andreas Ziegler
  • Jennifer H. Barrett
Visa allt

Summary, in English

An abnormal nevus phenotype is associated with an increased risk of melanoma. We report a pooled analysis conducted using individual nevus data from 15 case-control studies (5,421 melanoma cases and 6,966 controls). The aims were to quantify the risk better and to determine whether relative risk is varied by latitude. Bayesian unconditional logistic random coefficients models were employed to study the risk associated with nevus characteristics. Participants with whole body nevus counts in the highest of 4 population-based categories had a greatly increased risk of melanoma compared with those in the lowest category (pooled odds ratio (pOR) 6.9 (95% confidence interval (CI): 4.4, 1.1.2) for those aged <50 years and pOR 5.1 (95% CI: 3.6, 7.5) for those aged >= 50). The pOR for presence compared with absence of any clinically atypical nevi was 4.0 (95 % CI: 2.8, 5.8). The pORs for 1-2 and >= 3 large nevi on the body compared with none were 2.9 (95% CI: 1.9, 4.3) and 7.1 (95% CI: 4.7, 11.6), respectively. The relative heterogeneities among studies were small for most measures of nevus phenotype, except for the analysis of nevus counts on the arms, which may have been due to methodological differences among studies. The pooled analysis also suggested that an abnormal nevus phenotype is associated most with melanomas on intermittently sun-exposed sites. The presence of increased numbers of nevi, large nevi and clinically atypical nevi on the body are robust risk factors for melanoma showing little variation in relative risk among studies performed at different latitudes. (C) 2008 Wiley-Liss, Inc.

Publiceringsår

2009

Språk

Engelska

Sidor

420-428

Publikation/Tidskrift/Serie

International Journal of Cancer

Volym

124

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

John Wiley & Sons Inc.

Ämne

  • Cancer and Oncology

Nyckelord

  • Bayesian
  • pooled analysis
  • latitude
  • melanoma
  • nevus

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0020-7136