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Feedback control of Purkinje cell activity by the cerebello-olivary pathway.

Publiceringsår: 2004
Språk: Engelska
Sidor: 2999-3005
Publikation/Tidskrift/Serie: Eur J Neurosci
Volym: 20
Nummer: 11
Dokumenttyp: Artikel
Förlag: Blackwell Publishing


The pathway from the deep cerebellar nuclei to the inferior olive, the source of the climbing fibre input to the cerebellum, inhibits olivary transmission. As climbing fibre activity can depress the background firing of the Purkinje cells, it was suggested that nucleo-olivary (N–O) inhibition is a negative feedback mechanism for regulating Purkinje cell excitability. This suggestion was investigated, in a set-up with decerebrate ferrets, both by blocking and by stimulating cerebellar output while recording Purkinje cell activity. Blocking the N–O pathway was followed by an increased climbing fibre activity and a dramatic reduction in simple spike firing. Stimulation of the N–O fibres depressed climbing fibre responses and caused an increase in simple spike firing. These results are taken as support for the feedback hypothesis.



  • Neurosciences
  • climbing fibres
  • cerebellum
  • deep cerebellar nuclei
  • inferior olive
  • nucleo-olivary pathway


  • ISSN: 0953-816X

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