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ARAGORN, a program to detect tRNA genes and tmRNA genes in nucleotide sequences

Författare:
Publiceringsår: 2004
Språk: Engelska
Sidor: 11-16
Publikation/Tidskrift/Serie: Nucleic Acids Research
Volym: 32
Nummer: 1
Dokumenttyp: Artikel
Förlag: Oxford University Press

Sammanfattning

A computer program, ARAGORN, identifies tRNA and tmRNA genes. The program employs heuristic algorithms to predict tRNA secondary structure, based on homology with recognized tRNA consensus sequences and ability to form a base-paired cloverleaf. tmRNA genes are identified using a modified version of the BRUCE program. ARAGORN achieves a detection sensitivity of 99% from a set of 1290 eubacterial, eukaryotic and archaeal tRNA genes and detects all complete tmRNA sequences in the tmRNA database, improving on the performance of the BRUCE program. Recently discovered tmRNA genes in the chloroplasts of two species from the 'green' algae lineage are detected. The output of the program reports the proposed tRNA secondary structure and, for tmRNA genes, the secondary structure of the tRNA domain, the tmRNA gene sequence, the tag peptide and a list of organisms with matching tmRNA peptide tags.

Disputation

Nyckelord

  • Biology and Life Sciences

Övriga

Published
Yes
  • Microbial Ecology
  • ISSN: 1362-4962

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