Non-alcoholic Steatohepatitis Induces a Decrease in the Levels of S-100b in the Rat Brain

Summary, in English

Using an experimental model of non-alcoholic (alimentary-induced) steatohepatitis in rats, we found that this pathological condition created by consumption of a special diet for 16 weeks results in a drop in the brain mass (by 22%, on average) and also in decreases in the size and morphological modifications of astrocytes and the level of a calcium-binding protein, S-100b. The latter shifts were greater in the hindbrain, including the cerebellum (34.8%), than in the hemispheres, including the thalamus, hypothalamus, hippocampus, and cortex (18.0%).

• Författare: G. A. Ushakova; O. Z. Fomenko; Stefan Pierzynowski
• Avdelning/ar: Funktionell zoologi
• Publiceringsår: 2008
• Språk: Engelska
• Sidor: 316-318
• Publikation/Tidskrift/Serie: Neurophysiology
• Volym: 40
• Issue: 4
• Länkar: http://dx.doi.org/10.1007/s11062-009-9051-x
• Dokumenttyp: Artikel i tidskrift
• Förlag: Springer
• Ämne: Zoology
• Nyckelord: encephalopathy; hepatic; non-alcoholic steatohepatitis; S-100b; astrocytes
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 0090-2977