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Non-alcoholic Steatohepatitis Induces a Decrease in the Levels of S-100b in the Rat Brain

Författare:
Publiceringsår: 2008
Språk: Engelska
Sidor: 316-318
Publikation/Tidskrift/Serie: Neurophysiology
Volym: 40
Nummer: 4
Dokumenttyp: Artikel
Förlag: Springer

Sammanfattning

Using an experimental model of non-alcoholic (alimentary-induced) steatohepatitis in rats, we found that this pathological condition created by consumption of a special diet for 16 weeks results in a drop in the brain mass (by 22%, on average) and also in decreases in the size and morphological modifications of astrocytes and the level of a calcium-binding protein, S-100b. The latter shifts were greater in the hindbrain, including the cerebellum (34.8%), than in the hemispheres, including the thalamus, hypothalamus, hippocampus, and cortex (18.0%).

Disputation

Nyckelord

  • Biology and Life Sciences
  • encephalopathy
  • hepatic
  • non-alcoholic steatohepatitis
  • S-100b
  • astrocytes

Övriga

Published
Yes
  • ISSN: 0090-2977

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