Evaluation of two pairs of chiral stationary phases: Effects from the length of the achiral spacers
Författare
Summary, in English
Two pairs of chiral stationary phases (CSPs) with different C-2-symmetric central parts were prepared and evaluated by chromatography of a series of structurally different racemates. Within each pair, the selectors on which the CSPs are based had different lengths of their achiral spacers. The CSPs based on selectors with short spacers showed higher enantioselectivity than the phases incorporating long spacers. On one pair of the phases, a study of the influence from different retention modifiers was performed for a series of benzodiazepinones. This demonstrated the importance of the polymer structure formed from the selectors with different spacer lengths for the enantiodiscriminating ability of the CSPs. (C) 2004 Wiley-Liss, Inc.
Publiceringsår
2004
Språk
Engelska
Sidor
614-624
Publikation/Tidskrift/Serie
Chirality
Volym
16
Issue
9
Dokumenttyp
Artikel i tidskrift
Förlag
John Wiley & Sons Inc.
Ämne
- Organic Chemistry
Nyckelord
- enantioselective liquid chromatography
- racemate resolution
- selector
- synthesis
- benzodiazepinones
- multiple hydrogen bonding
Status
Published
Forskningsgrupp
- Chemical Biology and Therapeutics
ISBN/ISSN/Övrigt
- ISSN: 1520-636X