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Novel antibody specificities targeting glycoprotein B of cytomegalovirus identified by molecular library technology

Författare:
  • Fredrika Axelsson
  • Jonas Persson (Civ.Ing)
  • Emmanuel Moreau
  • Marie-Hélène Côté
  • Alain Lamarre
  • Mats Ohlin
Publiceringsår: 2009
Språk: Engelska
Sidor: 429-436
Publikation/Tidskrift/Serie: New Biotechnology
Volym: 25
Nummer: 6
Dokumenttyp: Artikel
Förlag: Elsevier B.V

Sammanfattning

Antibodies provide some protection against cytomegalovirus-mediated disease. All aspects of antibody recognition of important viral antigens are however not fully appreciated. Glycoprotein B (gB), a key protein in the viral membrane, participates in viral infection and it is a component of prototype vaccines. By using combinatorial antibody library and selection technology, novel antibody specificities targeting gB have now been isolated. We define a monoclonal antibody fragment able to recognize site I of antigenic domain (AD) 2, a poorly immunogenic epitope targeted by potent virus-neutralizing antibodies, in a way that is different from the binding of antibodies induced by infection but similar to those induced by vaccination. We also describe the existence of a novel epitope overlapping site I of AD-2 and AD-1, the immunodominant epitope of gB. These specificities, derived by molecular engineering, will be useful for the future assessment of humoral immune responses against this opportunistic viral infection.

Disputation

Nyckelord

  • Biology and Life Sciences

Övriga

Published
Yes
  • ISSN: 1871-6784

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