Synthesis of fused tetrazole derivatives via a tandem cycloaddition and N-allylation reaction and parallel synthesis of fused tetrazole amines
Författare
Summary, in English
A method for the synthesis of novel fused tricyclic tetrazoles from allylic bromides generated by the recently discovered DiazAll reaction has been developed. This new tandem reaction comprises a cycloaddition between a nitrile and (TMS)N-3 followed by an intramolecular N-allylation. The variation of functionalities in the benzene moiety was well-tolerated, and only a moderate difference in yield and degree of purity was noticed. An exo-methylene group in these new compounds permitted further derivatization. Structural resemblance with substances which possess important pharmacological properties motivated the synthesis of a series of ketones and a small library of amines.
Publiceringsår
2004
Språk
Engelska
Sidor
1346-1352
Publikation/Tidskrift/Serie
Journal of Organic Chemistry
Volym
69
Issue
4
Dokumenttyp
Artikel i tidskrift
Förlag
The American Chemical Society (ACS)
Ämne
- Organic Chemistry
Status
Published
Forskningsgrupp
- Chemical Biology and Therapeutics
ISBN/ISSN/Övrigt
- ISSN: 1520-6904