Biological and genetic evolution of HIV type 1 in two siblings with different patterns of disease progression
Författare
Summary, in English
To investigate the immunological and virological factors that may lead to different patterns of disease progression characteristic of HIV-1-infected children, two HIV-1-infected siblings, a slow and a fast progressor, were followed prospectively before the onset of highly active antiretroviral therapy. Viral coreceptor usage, including the use of CCR5/CXCR4 chimeric receptors, macrophage tropism, and sensitivity to the CC-chemokine RANTES, has been studied. An autologous and heterologous neutralizing antibody response has been documented using peripheral blood mononuclear cells- and GHOST(3) cell line-based assays. Viral evolution was investigated by env C2-V3 region sequence analysis. Although both siblings were infected with HIV-1 of the R5 phenotype, their viruses showed important biological differences. In the fast progressor there was a higher RANTES sensitivity of the early virus, an increased trend to change the mode of CCR5 receptor use, and a larger genetic evolution. Both children developed an autologous neutralizing antibody response starting from the second year with evidence of the continuous emergence of resistant variants. A marked viral genetic and phenotypic evolution was documented in the fast progressor sibling, which is accompanied by a high viral RANTES sensitivity and persistent neutralizing antibodies.
Avdelning/ar
- Avdelningen för medicinsk mikrobiologi
- Drug Target Discovery
Publiceringsår
2007
Språk
Engelska
Sidor
1531-1540
Publikation/Tidskrift/Serie
AIDS Research and Human Retroviruses
Volym
23
Issue
12
Dokumenttyp
Artikel i tidskrift
Förlag
Mary Ann Liebert, Inc.
Ämne
- Pharmacology and Toxicology
- Basic Medicine
- Microbiology in the medical area
Status
Published
Forskningsgrupp
- Drug Target Discovery
ISBN/ISSN/Övrigt
- ISSN: 1931-8405