Evaluation of the effects of exercise on insulin sensitivity in Arabian and Swedish women with type 2 diabetes.

Summary, in English

AIMS: The purpose of this study was to evaluate the effects of exercise on cardio-respiratory fitness and insulin sensitivity in sedentary, overweight Arabian and Swedish women with type 2 diabetes. METHODS: Eighteen Arabian and 14 Swedish women participated in a supervised 6-month resistance training and aerobic program of moderate intensity. Insulin sensitivity and VO(2max) were measured at entry to the study and after 3 and 6 months training. RESULTS: After 6 months exercise, insulin sensitivity (M-value) increased (2.7+/-1.4mgkg(-1)min(-1) vs. 3.4+/-2mgkg(-1)min(-1), p<0.05) in all patients and accounted for by an increase in non-oxidative glucose metabolism (0.3+/-1.1mgkg(-1)min(-1) vs. 1.5+/-1.5mgkg(-1)min(-1), p<0.005) with no significant difference between the ethnic groups. Notably, significant improvement in HbA1c was only seen in the Swedish patients who achieved greater exercise intensity (73.3+/-4.8% vs. 63.3+/-5.2% of maximum heart rate, p<0.005). No changes were observed regarding VO(2max) or lipid profile in either group. CONCLUSIONS: Although a 6-month exercise intervention of moderate intensity in Arabian and Swedish patients with type 2 diabetes can improve insulin sensitivity it is hampered by the metabolic inflexibility of switching between oxidation of glucose or fat.

• Författare: Forouzan Glans; Karl-Fredrik Eriksson; Åsa Tornberg; Ola Thorsson; Per Wollmer; Leif Groop
• Avdelning/ar: Translationell Muskel Forskning; Vaskulära sjukdomar - kliniska studier; Människan i rörelse: hälsa och rehabilitering; Klinisk fysiologi och nuklearmedicin, Malmö
• Publiceringsår: 2009
• Språk: Engelska
• Sidor: 69-74
• Publikation/Tidskrift/Serie: Diabetes Research and Clinical Practice
• Volym: 85
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/19447515?dopt=Abstract; http://dx.doi.org/10.1016/j.diabres.2009.04.018
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Endocrinology and Diabetes
• Status: Published
• Projekt: Fysik aktivitet, träning och kost vid typ 2 diabetes
• Forskningsgrupp: Genomics, Diabetes and Endocrinology; Vascular Diseases - Clinical Research; Human Movement: health and rehabilitation; Clinical Physiology, Malmö
• ISBN/ISSN/Övrigt: ISSN: 1872-8227