Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Biosynthesis, processing, and sorting of human myeloperoxidase.

Författare

Summary, in English

Exclusively synthesized by normal neutrophil and monocyte precursor cells, myeloperoxidase (MPO) functions not only in host defense by mediating efficient microbial killing but also can contribute to progressive tissue damage in chronic inflammatory states Such as atherosclerosis. The biosynthetic precursor, apoproMPO, is processed slowly in the ER, undergoing cotranslational N-glycosylation, transient interactions with the molecular chaperones calreticulin and calnexin, and heme incorporation to generate enzymatically active proMPO that is competent for export into the Golgi. After exiting the Golgi the propeptide is removed prior to final proteolytic processing in azurophil granules, resulting in formation of a symmetric MPO homodimer linked by a disulfide bond. Some proMPO escapes granule targeting and becomes constitutively secreted to the extracellular environment. Although the precise mechanism is Unknown, the pro-segirient is required for normal processing and targeting. as propeptide-deleted MPO precursor is either degraded or constitutively secreted. Characterizing the molecular consequences of naturally Occurring mutations that cause inherited MPO deficiency provides unique insight into the structural determinants of MPO involved in biosynthesis, processing and targeting. (C) 2005 Elsevier Inc. All rights reserved.

Publiceringsår

2006

Språk

Engelska

Sidor

214-224

Publikation/Tidskrift/Serie

Archives of Biochemistry and Biophysics

Volym

445

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

Academic Press

Ämne

  • Hematology

Nyckelord

  • inflammation
  • secretion
  • intracellular sorting
  • neutrophil
  • monocyte
  • calreticulin
  • calnexin
  • heme
  • lysosome
  • innate immunity

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0003-9861