Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia.
Författare
Summary, in English
A critical cell cycle regulatory protein, cyclin A1, has been implicated in the development of acute myeloid leukemia (AML). Here, we have examined the expression and clinical significance of cyclin A1 in childhood acute lymphoblastic leukemia (ALL). Cyclin A1 was highly expressed in lymphoblastic leukemic cell lines and in 22 of 30 ALL patients (73%). Cyclin A1 expression correlated with patient age (P=0.006), but not with cytogenetic abnormalities. Patients with high levels of cyclin A1 had poorer event-free survival (57.9%) compared to patients with lower levels (75%). (c) 2005 Elsevier Ltd. All rights reserved.
Publiceringsår
2006
Språk
Engelska
Sidor
254-261
Publikation/Tidskrift/Serie
Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
Volym
30
Issue
3
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Cancer and Oncology
Nyckelord
- cyclin A1
- cyclin dependent kinase
- event
- acute lymphoblastic leukemia
- free survival
- cell cycle
- disease characteristics
Status
Published
Forskningsgrupp
- Pathology, Malmö
ISBN/ISSN/Övrigt
- ISSN: 1873-5835