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Vaccination against atherosclerosis? Induction of atheroprotective immunity

In English

Författare

Summary, in English

Atherosclerosis involves the formation of inflammatory arterial lesions and is one of the most common causes of death globally. It has been evident for more than 20 years that adaptive immunity regulates the magnitude of the atherogenic proinflammatory response. T cells may also influence the stability of the atherosclerotic lesion and thus the propensity for thrombus formation and the clinical outcome of disease. Immunization of hypercholesterolemic animals with low-density lipoprotein preparations reduces atherosclerosis, suggesting that vaccination may represent a useful strategy for disease prevention or modulation. This review summarizes our current understanding of the role immunity in atherosclerosis and outlines strategies for antigen-specific prevention of this disease.

Publiceringsår

2009

Språk

Engelska

Sidor

95-101

Publikation/Tidskrift/Serie

Seminars in Immunopathology

Volym

31

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Springer

Ämne

  • Immunology in the medical area

Status

Published

Forskningsgrupp

  • Cardiovascular Research - Immunity and Atherosclerosis

ISBN/ISSN/Övrigt

  • ISSN: 1863-2300