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Association between plasma homocysteine levels and mortality in elderly patients with mental illness.

In English

Författare

Summary, in English

BACKGROUND/METHOD: Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness. Plasma tHcy is known to be associated with cardiovascular disease, renal impairment and negative lifestyle factors, and has been shown to predict mortality in human subjects. Epidemiological data on this topic in elderly patients with mental illness are missing. We therefore investigated the association between plasma tHcy levels and mortality in these patients. RESULTS: The group of deceased patients showed higher age, higher plasma tHcy, lower renal function and lower serum folate than patients who were still alive. Only age, plasma tHcy and the presence of vascular disease significantly influenced mortality. CONCLUSION: The association between plasma tHcy level and mortality risk was probably explained in part by the two plasma tHcy determinants age and presence of vascular disease. The determination of plasma tHcy in elderly patients with mental illness may help to identify patients in need of more intensive treatment.

Publiceringsår

2009

Språk

Engelska

Sidor

579-583

Publikation/Tidskrift/Serie

Dementia and Geriatric Cognitive Disorders

Volym

27

Issue

6

Dokumenttyp

Artikel i tidskrift

Förlag

Karger

Ämne

  • Pharmacology and Toxicology
  • Psychiatry
  • Medicinal Chemistry
  • Geriatrics

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1420-8008