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Does Longstanding Nicotine Exposure Impair Bone Healing and Osseointegration? An Experimental Study in Rabbits

In English

Författare

Summary, in English

Objectives: The aim of this study was to analyze the effect of longstanding nicotine exposure on bone healing and osseointegration of titanium implants. Materials and Methods: 20 female rabbits received either nicotine (n = 10) or saline (n = 10) administered subcutaneously via mini-osmotic pumps for 32 weeks. The pump delivered 6 mu g/kg/min of nicotine for the animals in the test group. Blood samples were collected and plasma cotinine levels were measured monthly. Six months after the commencement of nicotine or saline administration three osteotomy preparations, one in right, femoral condyle and two in the right tibia were made. One experimental implant was placed in the femur site and one in the most distal preparation of the tibia. The remaining site in the tibia was left empty. The osteotomy preparation and implant installation procedure was repeated in the left leg of the rabbits after 2 weeks. The implants in the tibial site were subjected to removal torque test (RMT) 2 weeks later. Block biopsies of the two other osteotomy sites were prepared for histological analysis. Results: Although no differences in RMT values were found between test and control groups, there was a significant increase in RMT between 2 and 4 weeks within each group. The histomorphometric analysis of bone-to-implant contact and bone density in the bone defects revealed no differences between the test and the control group after 2 or 4 weeks of healing. Conclusion: Longstanding (6 months) nicotine exposure did not impair bone healing and osseointegration of titanium implants. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 91B: 918-923, 2009

Publiceringsår

2009

Språk

Engelska

Sidor

918-923

Publikation/Tidskrift/Serie

Journal of Biomedical Materials Research. Part B - Applied Biomaterials

Volym

91B

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

John Wiley & Sons Inc.

Ämne

  • Environmental Health and Occupational Health

Nyckelord

  • resonance frequency analysis
  • removal torque test
  • implants
  • bone healing
  • Smoking
  • nicotine
  • histomorphometry

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1552-4981