Direct resolution of naproxen on a non-covalently molecularly imprinted chiral stationary phase
Författare
Summary, in English
A synthetic polymer selective for (S)-naproxen was prepared by molecular imprinting. 4-Vinylpyridine and ethylene glycol dimethacrylate were copolymerised in the presence of the template, (S)-naproxen. The template was extracted from the polymer, leaving specific recognition sites, complementary to the template. The polymer was utilized as a stationary phase in HPLC. Racemic naproxen was efficiently resolved on the polymer. Furthermore, the polymer was able to separate naproxen from the structurally related ibuprofen and ketoprofen.
Avdelning/ar
Publiceringsår
1994
Språk
Engelska
Sidor
276-279
Publikation/Tidskrift/Serie
Journal of Chromatography A
Volym
664
Issue
2
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Biochemistry and Molecular Biology
Status
Published
Forskningsgrupp
- Nanomedicine and Biomaterials
ISBN/ISSN/Övrigt
- ISSN: 0021-9673