Nanosphere induced gene expression in human dendritic cells
Författare
Summary, in English
The molecular mechanisms of nanosphere-induced mucosal immunization are important to decipher, since this can form the basis for novel approaches in, e.g., nasal vaccination. In this study, we have investigated the effect of nanospheres as antigen carriers on immature human dendritic cells. The results clearly indicate that tetanus toxoid immobilized nanospheres have a direct effect on human monocyte derived dendritic cells and induce a specific transcriptional profile involving genes crucial for phagocytosis and a protective immune response.
Avdelning/ar
Publiceringsår
2005
Språk
Engelska
Sidor
2168-2173
Publikation/Tidskrift/Serie
Nano Letters
Volym
5
Issue
11
Dokumenttyp
Artikel i tidskrift
Förlag
The American Chemical Society (ACS)
Ämne
- Nano Technology
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1530-6992