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Nanosphere induced gene expression in human dendritic cells

Publiceringsår: 2005
Språk: Engelska
Sidor: 2168-2173
Publikation/Tidskrift/Serie: Nano Letters
Volym: 5
Nummer: 11
Dokumenttyp: Artikel
Förlag: American Chemical Society


The molecular mechanisms of nanosphere-induced mucosal immunization are important to decipher, since this can form the basis for novel approaches in, e.g., nasal vaccination. In this study, we have investigated the effect of nanospheres as antigen carriers on immature human dendritic cells. The results clearly indicate that tetanus toxoid immobilized nanospheres have a direct effect on human monocyte derived dendritic cells and induce a specific transcriptional profile involving genes crucial for phagocytosis and a protective immune response.



  • Chemistry


  • ISSN: 1530-6984

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