Synthesis of decaline analogues of isovelleral

Summary, in English

Decaline analogues of the bioactive fungal sesquiterpene (+)-isovelleral (1a), retaining the bicyclo[4,1,0]hept-2-en-1,2-dicarbaldehyde system, were prepared, and their cytotoxic and antimicrobial activities were compared with those of the natural product. While the two isomers (+/-)-2 and (+/-)-3 were as active as isovelleral (1a), the isomer (+/-)-4 was approximately 10 times less potent.

• Författare: Martin H Johansson; I Aujard; Daniel Röme; H Anke; Olov Sterner
• Avdelning/ar: Centrum för analys och syntes
• Publiceringsår: 2005
• Språk: Engelska
• Sidor: 984-989
• Publikation/Tidskrift/Serie: Zeitschrift fuer Naturforschung. Section B: A Journal of Chemical Sciences
• Volym: 60
• Issue: 9
• Länkar: http://www.znaturforsch.com/ab/v60b/60b0984.pdf; http://www.znaturforsch.com/ab/v60b/c60b.htm#No9
• Dokumenttyp: Artikel i tidskrift
• Förlag: Verlag der Zeitschrift für Naturforschung
• Ämne: Organic Chemistry
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 0932-0776