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Influence of salt ions on binding to molecularly imprinted polymers.

In English

Författare

Summary, in English

Salt ions were found to have an influence on template binding to two model molecularly imprinted polymers (MIPs), targeted to penicillin G and propranolol, respectively, in water-acetonitrile mixtures. Water was detrimental to rebinding of penicillin G whereas propranolol bound in the entire water-acetonitrile range tested. In 100% aqueous solution, 3-M salt solutions augmented the binding of both templates. The effects followed the Hofmeister series with kosmotropic ions promoting the largest increase. Binding was mainly of a non-specific nature under these conditions. In acetonitrile containing low amounts of water, the specific binding to the MIPs increased with the addition of salts. Binding of penicillin G followed the Hofmeister series while an ion-exchange mechanism was observed for propranolol. The results suggest that hydration of kosmotropic ions reduces the water activity in water-poor media providing a stabilizing effect on water-sensitive MIP-template interactions. The effects were utilized to develop a procedure for molecularly imprinted solid-phase extraction (MISPE) of penicillin G from milk with a recovery of 87%.

Publiceringsår

2010

Språk

Engelska

Sidor

1599-1606

Publikation/Tidskrift/Serie

Analytical and Bioanalytical Chemistry

Volym

396

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

Springer

Ämne

  • Analytical Chemistry

Status

Published

Forskningsgrupp

  • Nanomedicine and Biomaterials

ISBN/ISSN/Övrigt

  • ISSN: 1618-2642