Is Increased Thrombin Activation in Patients With Abdominal Aortic Aneurysms Dependent on Area or Volume of Aneurysm Thrombus Mass?
Författare
Summary, in English
Objectives: Does thrombin activation seen in patients with abdominal aortic aneurysms (AAA) relate to the thrombus surface area or volume within the aneurysm? Patients and methods: A total of 130 patients with AAA were analyzed regarding levels of the complex between activated protein C-protein C inhibitor (APC-PCI) and AAA morphology. Analysis of APC-PCI complex was made using a sandwich immunofluorometric method. Results: Increased APC-PCI concentrations were seen in patients with AAA (0.44 mu g/L; P < .001 compared with controls). The correlations of APC-PCI values were r = .13, P = .13 for aneurysm size, r = .08, P = .35 for thrombus surface area, and r = .13, P = .14 for thrombus volume. APC-PCI values elevated to 0.45 mu g/L in 10 patients with AAA having no or very little thrombus mass. Conclusion: Disappointingly, no correlation was found between thrombus surface area or volume and levels of the APC-PCI complex. Mechanisms other than the AAA-sac thrombus must be evaluated as cause of thrombin activation in patients with AAA.
Publiceringsår
2010
Språk
Engelska
Sidor
113-118
Publikation/Tidskrift/Serie
Angiology
Volym
61
Issue
1
Dokumenttyp
Artikel i tidskrift
Förlag
SAGE Publications
Ämne
- Medicinal Chemistry
- Cardiac and Cardiovascular Systems
Nyckelord
- Abdominal aortic aneurysm
- Aneurysm thrombus
- Coagulation activation
- Thrombin activation
Status
Published
Forskningsgrupp
- Vascular Diseases - Clinical Research
- Clinical Chemistry, Malmö
ISBN/ISSN/Övrigt
- ISSN: 0003-3197