Prion-like transmission of protein aggregates in neurodegenerative diseases.

Summary, in English

Neurodegenerative diseases are commonly associated with the accumulation of intracellular or extracellular protein aggregates. Recent studies suggest that these aggregates are capable of crossing cellular membranes and can directly contribute to the propagation of neurodegenerative disease pathogenesis. We propose that, once initiated, neuropathological changes might spread in a 'prion-like' manner and that disease progression is associated with the intercellular transfer of pathogenic proteins. The transfer of naked infectious particles between cells could therefore be a target for new disease-modifying therapies.

• Författare: Patrik Brundin; Ronald Melki; Ron Kopito
• Avdelning/ar: Institutionen för experimentell medicinsk vetenskap; MultiPark: Multidisciplinary research focused on Parkinson´s disease
• Publiceringsår: 2010
• Språk: Engelska
• Sidor: 301-307
• Publikation/Tidskrift/Serie: Nature Reviews. Molecular Cell Biology
• Volym: 11
• Issue: 4
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/20308987?dopt=Abstract; http://dx.doi.org/10.1038/nrm2873
• Dokumenttyp: Artikel i tidskrift
• Förlag: Nature Publishing Group
• Ämne: Neurosciences
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1471-0072