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Elevated neutrophil, macrophage and dendritic cell numbers characterize immune cell populations in mice chronically infected with Salmonella.

In English

Författare

Summary, in English

The present study characterizes immune cell populations in mice chronically infected with Salmonella. Mice were characterized as chronically infected based on persistently high titers of Salmonella-reactive immunoglobulins in the serum > 6 months after a single oral dose of S. enterica serovar Typhimurium. These mice had a visibly enlarged spleen but not liver, while both organs harbored bacteria and had increased total cellularity up to 11 months post-infection. Flow cytometry analysis revealed significantly elevated numbers of neutrophils, dendritic cells (DC) and macrophages in the spleen of chronically infected mice. In contrast, no significant increase in the absolute number of T and B cells was apparent in the spleen and DX5(+) cells, which includes NK cells, some NK T cells and possibly some activated T cells, appears to correlate with chronic Salmonella infection in the liver but not the spleen. In situ analyses revealed that CD8(alpha)(+) DC and Gr-1(+) cells (neutrophils) increased in the splenic red pulp of chronically infected mice. In addition,,Gr-1(+) cells, CD68(+) cells and CD11c(+) cells (DC), the latter lacking detectable staining for CD8 alpha and CD4, accumulated around hepatic blood vessels and in the hepatic network in the liver of mice chronically harboring bacteria. These data provide insight into changes that occur within immune cell populations, most notably within splenic and hepatic phagocytic cell populations, that accompany chronic infection with the intracellular bacterium Salmonella. (c) 2006 Elsevier Ltd. All rights reserved.

Avdelning/ar

Publiceringsår

2006

Språk

Engelska

Sidor

49-58

Publikation/Tidskrift/Serie

Microbial Pathogenesis

Volym

41

Issue

2-3

Dokumenttyp

Artikel i tidskrift

Förlag

Academic Press

Ämne

  • Infectious Medicine

Nyckelord

  • dendritic cell
  • infection
  • salmonella
  • macrophage
  • lymphocytes

Status

Published

Forskningsgrupp

  • Immunology

ISBN/ISSN/Övrigt

  • ISSN: 1096-1208